广州中法霍夫曼研究所所长基础医学医药科学创新人物中国科技创新(2)

3. 建立了GP73的检测试剂盒，利用临床肝癌肝炎病人样本做了前期测试，发现GP73比传统诊断标志物AFP更具有灵敏性和特异性。此后中国医学科学院通过大规模的临床实验也证实了GP73作为肝癌诊断标志物的特异性和灵敏性。

4.创建了佛山市烨泰科技有限公司，成为中国科学院南海生物医药科技产业中心首批入驻企业。开发了用于致病微生物现场检测的分子诊断微系统。 同时，公司还基于项目组自主筛选的GP73蛋白单克隆抗体，开发了用于肝癌早期诊断的GP73 ELISA定量检测试剂盒，在检测灵敏度及特异性方面都优于传统的甲胎蛋白，对早期发现肝癌、治疗肝癌、提高肝癌患者的生存质量具有重要意义。

发明专利：

申请专利10多项，获得包括国际专利“可溶性疱疹病毒蛋白复合体疫苗”在内的7项发明专利授权。

资料更新中……

论文专著：

1.主编《核酸等温扩增技术及其应用》科学出版社 2009.

2.编译了《临床病毒学》2012。

3.参编《分子基因药物学》第九章：“丙型肝炎病毒分子病毒学”2008。

4.参编《新药发现开发技术平台》五章：“现代医药中天然药物开发技术平台” 2007李其翔;彭涛;刘国红。

代表性论文：

1. Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1 /Liver-Specific PGC-1 Upregulation. Wenxia Yao, Hua Cai, Tao Peng. J Virol.

2. GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation. Fang Wang, Tao Peng * Cell Biol Int.

3. Epithelium-Specific ETS (ESE)-1 Upregulated GP73 Expression in Hepatocellular Carcinoma Cells. Fang Wang, Tao Peng *.Cell & Bioscience.

4. Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin. PLoS One.

5. GP73 Is Upregulated by Hepatitis C Virus (HCV) Infection and Enhances HCV Secretion. PLoS One.

6. 李新磊,彭涛*Xinlei Li,Tao Peng * 丙型肝炎病毒体外细胞培养系统研究进展The current progress in the development of hepatitis C virus cell culture systems 中国病毒病杂志 Chin J Viral Dis

7. Hongling Wu，Ting Li，Musheng Zeng and Tao Peng “Herpes simplex virus type 1 infection activates the Epstein–Barr virus replicative cycle via a CREB-dependent mechanism” Cellular Microbiology，Dec 2011 22．doi： 10．1111/j．1462-5822．2011．01740．x．

8. Longbo Hu，Leike Li，Hongbin Xie，Yanli Gu and Tao Peng，“The Golgi Localization of GOLPH2 （GP73/GOLM1） Is Determined by the Transmembrane and Cytoplamic Sequences” PLoS One，Nov 2011，Vol 6，Issue 11，e28207.

9. Yi Wang, Qi Wang, Qinchang Zhu, Rong Zhou, Jinsong Liua*, Tao Peng* Identification and Characterization of Acyclovir-resistant Clinical HSV-1 Isolates from Children. Journal of Clinical Virology 2011, doi:10.1016/j.jcv.2011.06.009.

10. Jian Xie, Pengwei Zhang, Chuanjiang Li, Qianhua Huang, Rong Zhou, Tao Peng* Mechanistic Insights into the Roles of Three Linked Single-Stranded Template Binding Residues of MMLV Reverse Transcriptase in Misincorporation and Mispair Extension Fidelity of DNA Synthesis. Gene 2011, Jun 15;479(1-2):47-56.

11. Ruiqi Zhang, Xia Rong, Weiqi Pan, Tao Peng* Determination of Sera Neutralization Antibodies Against the Seasonal Strain H3N2 and the Emerging Strains 2009 H1N1 and Avian H5N1 Scandinavian Journal of Infectious Diseases 2011. Mar;43(3):216-20.

12. Tao Peng*. Strategies for Antiviral Screening Targeting Early Steps of Virus Infection. Virologica Sinica 2010 Vol.4:281-293.

13. Fangfang Zhang, Yanli Gu, Xiang Li, Wei Wang, Jianxing He*, Tao Peng* Up-regulated Golgi Phosphoprotein 2 (GOLPH2) Expression in Lung Adenocarcinoma Tissue. Clinical Biochemistry 2010 (online ahead of publication). doi: 10.1016/j.clinbiochem.2010.05.010.

14. Qin-Chang Zhu, Yi Wang and Tao Peng* Herpes Simplex Virus (HSV) Immediate-Early (IE) Promoter-Directed Reporter System for the Screening of Antiherpetics Targeting the Early Stage of HSV Infection. Journal of Biomolecular Screening 2010. July: DOI: 10.1177/1087057110372804.

15. Yan Zhou, Leike Li, Longbo Hu, Tao Peng* Golgi phosphoprotein 2 (GOLPH2/GP73/GOLM1) interacts with secretory clusterin. 2010 Mol Biol Rep.. doi:10.1007/s11033-010-0251-7.

16. Yanli Gu, Wenli Chen, Yu Zhao, Liyun Chen and Tao Peng*. Quantitative Analysis of Elevated Serum Golgi Protein-73 Expression in Patients with Liver Diseases. Ann Clin Biochem 2009; 46: 38–43.

17. Wenjuan Gao, Xiang Li, Lingwen Zeng and Tao Peng*. Rapid isothermal detection assay: a probe amplification method for the detection of nucleic acids. Diag Microbiol Infect Dis. 2008, 60: 133-141.

18. Xiang Li and Tao Peng*. A New Rapid Isothermal Nucleic Acid Detection Method. Chinese Journal of Laboratory Medicine, 2008 Vol. 31, No.3 322-324.

19. Hongbin Xie, Yu Gong and Tao Peng*. Cloning of the Promoter Regions of Golgi Membrane Glycoprotein GP73. Agricultural Science and Technology. 2008 Vol. 9, No.3.